Microencapsulate technology shows promise for weight-management applications, according to proof-of-concept studyhttp://www.nutritionaloutlook.com/weight-management-nutrition/microencapsulate-technology-shows-promise-weight-management-applications-according-proof-concept?topic=521&eid=380829564&bid=2323463... read more
Dr. Sinéad B. Bleiel, Company Founder & Director of AnaBio Technologies LTD. Ireland, will be speaking at Vitafoods this week.If you would like to know more details about this event see details in the link below: https://www.vitafoods.eu.com/en/welcome.html Please see full details below: Wednesday 10th May At Life Stages Theatre Time: 14:15 – 14:45 ENCAPSULATION OF MACRONUTRIENTS FOR... read more
AnaBio collaborates with Prof. Brayden in UCD to tackle issues relating to delivery of oral peptidesAnaBio collaborates with Prof. Brayden in UCD to tackle issues relating to delivery of oral peptides. Joanne Heade presents novel findings. Please view full image here... read more
One of AnaBio’s greatest achievements involves the development of cost efficient encapsulation systems using natural, food-grade, low-cost materials with no artificial additives, excipients or agents. Hence, AnaBio provides bespoke scientific ‘know-how’ and novel ingredient delivery systems for industry clients seeking to access new markets or planning product upgrades. At present, AnaBio is working with milk and vegetable proteins, hydrocolloids, fibres, prebiotics and plant extracts to generate innovative capsule systems. To date, AnaBio has formulated patented encapsulation systems using UHT milk, proteins (vegetable and dairy), citrus fibres, prebiotics, pectins, carrageenans and alginate mixtures.
Awards & Nominations
Emerging Company of the Year 2014
Bank of Ireland IGNITE Company of the Year 2013
Outstanding Person of the Year 2013
Cork Person of the Month (August) 2013
Finalist for Emerging Company of the Year 2013
Finalist for Cork Person of the Year 2013
Publications & Links
Doherty, S.B., Gee, V.L., Ross, R.P., Stanton, C., Fitzgerald, G.F., and Brodkorb, A., 2010. Efficacy of whey protein gel networks as potential viability-enhancing scaffolds for cell immobilization of Lactobacillus rhamnosus GG. Journal of Microbiological Methods. 80, 231-241.
Doherty, S.B., Wang, L., Ross, R.P., Stanton, C., Fitzgerald, G.F., Brodkorb, A., 2010a. Use of viability staining in combination with Flow Cytometry for rapid viability assessment of Lactobacillus rhamnosus GG in complex protein matrices. Journal of Microbiological Methods. 82, 301-310.
Doherty, Auty, M.A., Ross, R.P., Stanton, C., Fitzgerald, G.F., Brodkorb, A., 2011a. Development and characterisation of whey protein micro-beads as potential matrices for probiotic protection. Food Hydrocolloids 25, 1604-1617.
Doherty, S.B., Auty, M.A., Stanton, C., Ross, R.P., Fitzgerald, G.F., Brodkorb, 2011b. Survival of entrapped Lactobacillus rhamnosus GG in whey protein micro-beads during simulated ex vivo gastro-intestinal transit. International Dairy Journal, In Press (September 2011).
Doherty, S.B., Upadrasta, A., Lawlor, P.G., Ross, R.P., Stanton, C., Fitzgerald, G.F., Brodkorb, A., 2011c. Evaluation of whey protein micro-bead transit time in the porcine gastro-intestinal tract, Journal of Microencapsulation, Accepted, October 2011.
Doherty, S.B., Auty, M.A., Ross, R.P., Stanton, C., Fitzgerald, G.F., Brodkorb, A., 2011d. Application of whey protein micro-bead coatings for enhanced strength and probiotic protection during fruit juice storage and gastric incubation, Journal of Micriencapsulation, Accepted, October, 2011.
Doherty, S.B., Upadrasta, A., Auty, M.A.E., Lawlor, P.G., Walsh, M.C., Ross, R.P., Stanton, C., Fitzgerald, G.F. and Brodkorb, A. (2011e). Application of whey protein micro-beads for improved probiotic delivery and functionality during in vivo gastro- intestinal transit, Submitted.
Pre/probiotic encapsulation technology for novel infant and toddler formulations. (Presentation) Probiota 2014, Amsterdam, The Netherlands, 4-5th February 2014.
Kent R.M., Stack H.M., O’Connor P.M., Fitzgerald G.F., Hill C., Stanton C., Ross R.P. Enzymatic production of casein-derived bioactive peptides; In silico prediction to pilot scale. Submission in progress
Guinane C.M., Kent R.M., O’Connor P.M., Fitzgerald G.F., Hill C., Stanton C., Ross R.P. Recombinant Lactobacillus paracasei strain producing active gut hormone Glucagon-like peptide-1 (GLP-1). Submission in progress
Maher S., Heade J., Waters S., Bleiel S.B., Brayden D.J., (2018), “Effects of surfactant-based permeation enhancers on mannitol permeability, histology, and electrogenic ion transport responses in excised rat colonic mucosae” Int. J. Pharm
Prieto M.L., O’Sullivan L., Tan S.P., McLoughlin P., Hughes H., O’Donovan O. Rea M.C., Kent R.M., Cassidy, J.P., Gardiner G.E., Lawlor P.G. Evaluation of the efficacy and safety of a marine-derived Bacillus strain for use as an in-feed probiotic for newly weaned pigs PLoS One. 2014 (Accepted for Publication)
Kent R.M., Guinane C.M., O’Connor P.M., Fitzgerald G.F., Hill C., Stanton C., Ross R.P. Production of the antimicrobial peptides caseicin A and B by Bacillus isolates growing on sodium caseinate. Letters in Applied Microbiology 2012 Aug; 55(2): 141-148.
O’Sullivan O.O., Kent R.M., Stack H.M., Fitzgerald G.F., Stanton C., Ross R.P. The genome sequence of the probiotic lactic acid bacteria, Lactobacillus paracasei NFBC 338. (Poster presentation) LAB 10: 10th Symposium on Lactic Acid Bacteria; Egmond an Zee, The Netherlands, Aug. 28th-Sept. 1st 2011.
Heade J., Maher S., Bleiel S.B., Brayden D.J., (2018), “Labrasol® and salts of medium chain fatty acids can be combined in low concentrations to increase the permeability of a macromolecule marker across isolated rat intestinal mucosae” J. Pharm. Sci. (under review)
Guinane C.M., Kent R.M., Norberg S., Hill C., Fitzgerald G.F., Stanton C., Ross R.P.Host specific diversity in Lactobacillus johnsonii as evidenced by a major chromosomal inversion and phage resistance mechanisms. PLoS One. 2011 Apr 20;6(4):e18740.
Guinane C.M., Kent R.M., Hill C., Fitzgerald G.F., Stanton C., Ross R.P Genomic rearrangements in the intestinal bacterium Lactobacillus johnsonii. (Poster presentation) US/Ireland Functional Foods Conference 2010, Cork, Ireland.
RM Kent, SB Doherty: Probiotic bacteria in infant formula and follow-up formula: Microencapsulation using milk and pea proteins to improve microbiological quality – Food research international, 2014 – Elsevier
PM Ryan, E Patterson, RM Kent, H Stack… Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents; – Scientific Reports, 2017
SB Bleiel, RM Kent, A Brodkorb Encapsulation Efficiency and Capacity of Bioactive Delivery Systems Engineering Foods for Bioactives 2017
CM Guinane, RM Kent, S Norberg, PM O’Connor… Generation of the antimicrobial peptide caseicin A from casein by hydrolysis with thermolysin enzymes – International Dairy Journal, 2015 – Elsevier
Plasma Creatine Kinetics After Ingestion of Microencapsulated Creatine Monohydrate with Enhanced Stability in Aqueous Solutions
M Hone, RM Kent, A Scotto di Palumbo… – Journal of dietary Supplements 2017
Maher S. Ryan B. Duffy A. and Brayden D.J. (2014). Formulation strategies to improve oral peptide delivery: a patent review. Pharmaceutical Patent analyst (submitted)
Gaudel C. Nongonierma AB. Maher S. Flynn S. Krause M. Murray BA. Kelly PM. Baird AW FitzGerald RJ Newsholme P. (2013) Effect of a whey protein hydrolysate on insulin secretion from a clonal pancreatic beta cell line and influence on glycemic function in ob/ob mice. Journal of Nutrition 143(7):1109-14
Petersen SB, Nolan G, Maher S, Rahbek UL, Guldbrandt M, Brayden DJ (2012). Evaluation of alkyl maltosides as intestinal permeation enhancers: Comparison between rat intestinal mucosal sheets and Caco-2 monolayers. European Journal of Pharmaceutical Science (47(4):701-12)
Mohan HM, Collins D, Walsh EG, Maher S, Winter DC, O’Brien PJ, Brayden DJ, Baird AW (2012) The Mycotoxin Patulin Increases Colonic Epithelial Permeability in Vitro. Food and Chemical Toxicology (50(11):4097-102).
Bahar B, O’Doherty JV, Maher S, McMorrow J, Sweeney T (2012) Chitooligosaccharide elicits acute inflammatory cytokine response through AP-1 pathway in human intestinal epithelial-like (Caco-2) cells Molecular Immunology 51, (3-4), 283-291.
Maher S. and Brayden D.J. (2011). Overcoming poor permeability: Translating permeation enhancers for oral peptide delivery. Drug Discovery Today Technologies 9 (2) e13-e1
Walsh EG, Adamczyk BE, Chalasani KB, Maher S, O’Toole EB, Fox JS, Leonard TW, Brayden DJ (2011) Oral delivery of macromolecules: rationale underpinning gastrointestinal permeation enhancement technology (GIPET®). Therapeutic Delivery 2, (12) 1595-1610.
Walsh EG, Maher S. O’Brien PJ, Baird AW, Brayden DJ (2011). High content screening to determine cytotoxicity of the antimicrobial peptide melittin and selected structural analogues. Peptides 32 (8) 1764-1773
Wang X, Maher S, Brayden DJ (2010). Rapid restoration of the colonic epithelium of rats after in situ instillation of the absorption promoter, sodium caprate. Therapeutic Delivery 1 (1) 75-82.
Brayden DJ and Maher S (2010). Oral absorption enhancement-taking the next steps in therapeutic delivery. Therapeutic Delivery 1 (1) 5-9.
Maher S, Devocelle M, Ryan S, McClean S, Brayden DJ (2010). Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin. International Journal of Pharmaceutics 387 (1-2) 154 160.
Maher S, Leonard M, Jacobsen J, Brayden DJ (2009). Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro and in vivo studies. Advanced Drug Delivery Reviews 61(15) 1427-49.
Maher S, Wang X, McClean S, Brayden DJ (2009). Evaluation of intestinal absorption enhancement and local mucosal toxicity of melittin and sodium caprate II: In situ rat instillation and perfusion. European Journal of Pharmaceutical Science 38(4):301-11.
Maher S, Kennelly R, Bzik V, Baird A, Winters DC, Brayden DJ (2009). Evaluation of intestinal absorption enhancement and local mucosal toxicity of melittin and sodium caprate I: Isolated rat and human colonic mucosa. European Journal of Pharmaceutical Science 38(4):291-300
Maher S, Vilk G, Kelleher F, Lajoie G, McClean S (2009). Chemical modification of the carboxyl terminal of nisin A with biotin does not abolish antimicrobial activity against indicator organism, Kocuria rhizophila. Peptide Research and therapeutics 15: 219-226.
Maher S, Brayden DJ, Feighery L, McClean S (2008). Cracking the junction: update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drugs. Critical reviews in Therapeutic Drug Carrier Systems 25:117-68.
Maher S, McClean S (2008). Melittin exhibits necrotic cytotoxicity in gastrointestinal cells which is attenuated by cholesterol. Biochemical Pharmacology 75:1104-14.
Maher S, Feighery L, Brayden DJ, McClean S (2007). Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae. Pharmaceutical Research 24:1346-56.
Maher S, Feighery L, Brayden DJ, McClean S (2007). Melittin as an epithelial permeability enhancer I: investigation of its mechanism of action in Caco-2 monolayers. Pharmaceutical research 24:1336-45.
Maher S, McClean S (2006). Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro. Biochemical Pharmacology 71:1289-98.
Non Peer Reviewed
Maher S. Farrell A. (2012) Delivering the Benefits of Functional Foods (Dairy Industry International)
“Flow Cytometry – Recent Perspectives”, ISBN 979-953-307-355-1
Maher S, Ahmad T, Ryan K, O’Driscoll CM, Brayden DJ, (2011). Nanostructures Overcoming the Intestinal Barrier: Physiological Considerations and Mechanistic Issues. In Alonso MJ and Csaba NS (Eds) Nanostructured biomaterials for overcoming biological barriers. RCS Publishing, UK Chapter II (39-62)
Ryan K, Maher S, Brayden DJ, O’Driscoll CM (2012). Nanostructures Overcoming the Intestinal Barrier: Drug Delivery Strategies. In Alonso MJ and Csaba NS (Eds) Nanostructured biomaterials for overcoming biological barriers. RCS Publishing, UK (63-90)
Brodkorb, A., Doherty, S., Ross, P. R., Fitzgerald, G., & Stanton, C. (2009). Bioencapsulation- creating a safe haven for sensitive ingredients. Tnet Research, 4 (1).