Importance of Antioxidants

Reactive oxygen species (ROS) are free radicals generated as a result of normal metabolism, but the habits of a poor-quality lifestyle (unbalanced diet, cigarette smoking, alcohol, ultraviolet radiation, etc.) also increase their production. Oxidative stress caused by ROS promote the aging process and development of degenerative diseases, such as cancer, heart disease or cataracts1. Likewise, lipid oxidation in food is one of the main causes of deterioration, causing rancidity, odd flavours, detriment of nutritional value and the generation of toxic compounds2.

Dietary antioxidants can help to fight against the oxidative damage (Valenzuela et al., 2003), while providing additional health benefits such as anti-inflammatory effect, enhanced digestion, protection against gastric ulcers and anticancer properties. Natural antioxidants, mainly derived from plants, can also be incorporated into food formulation, aiming to replace toxic synthetic antioxidants, such as BHA and BHT.

However, the technical characteristics of antioxidants compounds can compromise their application. AnaBio’s micro-encapsulated systems provide an effective approach towards these drawbacks, generating a more stable product during storage, enhanced solubility, thermal protection and flavour masking. These advances enable higher production yields and market expansion for new opportunities in food supplements, ready-to-take food products, drinks and beverages categories

Turmeric extract– Curcumin: The Antioxidant solution for the future

Turmeric extract (Curcuma longa) is a yellow-coloured spice obtained from the root of the Turmeric plant, which has been traditionally used as medical herb in Asian countries. The main bioactive compound of Turmeric is the Curcumin, which belongs to the polyphenol family, expected to show the highest growth in the global Antioxidant market. However, the utilization of Curcumin in food supplements is problematic due to its low water solubility, poor chemical stability and low oral bioavailability. Micro-encapsulation of curcumin in delivery systems is a promising solution for enhancing the application of this powerful antioxidant.

Curcumin for Sports recovery

Regular moderate exercise is considered beneficial against oxidative stress, however, an extreme aerobic-anaerobic training can increase the generation of ROS. As a result, the consumption of antioxidant supplementation has sharply increased in the recent years 3.

Antioxidants with high content in polyphenols, as Curcumin, are more effective for the recovery following exercise. More specifically, muscle damage induced by extreme exercise can be attenuated by Curcumin4, which appears to be an ideal antioxidant for sports recovery.

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AnaBio’s target delivery systems

OPTION 1: AnaBio’s property drying technology

  • Particle size < 300 µm
  • Excellent flowability
  • Superior protection against light-O2/thermal/enzymatic degradation
  • Suitable for food and supplement fortification

Figure 1. Light microscope micrography at 50X magnification of Curcumin microcapsules obtained by AnaBio’s property drying technology.

OPTION 2: AnaBio’s alternative drying technology

  • Particle size < 100 µm
  • Excellent flowability
  • Advantageous protection against light-O2/thermal/enzymatic degradation
  • Suitable for food and supplement
  • Suitable for beverage formulations
  • Enhanced solubility

Figure 2. Light microscope micrography at 50X magnification of Curcumin microcapsules obtained by AnaBio’s alternative proprietary technology.

Matrixes

AnaBio Technologies LTD has based the micro-encapsulation of Curcumin in the utilization of different biopolymers suitable for vegetarian and vegan consumption. These ingredients provide the necessary protection to Curcumin, and a suitable nutritional supplementation based on the incorporation of specific micro and macronutrients.

1.Enhanced water solubility & wettability

AnaBio Technology LTD provides enhanced Curcumin solubility and wettability, proven in different product applications. These characteristics potentially enhance curcumin bioavailability and create a plethora of new product applications, including low pH beverages, highly-fortified drinks / shots. Enhanced wettability reduced formulation preparation times for consumers and formulators alike.

Figure 3. Images taken for Curcumin solutions in different fluids. Non-encapsulated extract and Curcumin microcapsules obtained by Spray drying and AnaBio’s property drying technology.

2. Enhanced chemical stability

AnaBio Technologies LTD provide an enhanced resistance against pH in the presence of digestive enzymes. This buffering effect prevents clumping of curcumin & directly impacts bioavailability.

Figure 4. Effect of pH and digestive enzymes in the load of Curcumin.

3. Enhanced oral bioavailability

AnaBio Technologies LTD has generated Curcumin microcapsules with proven enhanced solubility and pH resistance. In addition, the different matrix generated, allow the incorporation of metabolism inhibitors which would allow to enhance the pharmacokinetics profile of Curcumin, in terms of its metabolism and elimination. Since curcumin is a highly hydrophobic molecule, similar to the proteins used in AnaBio’s micro-encapsulation system; this synergistic effect endorses curcumin uptake and bioavailability in the body.

4.Enhanced thermal resistance and oxidation

AnaBio Technologies LTD has generated Curcumin microcapsules with proven enhanced solubility and pH resistance. In addition, the different matrix generated, allow the incorporation of metabolism inhibitors which would allow to enhance the pharmacokinetics profile of Curcumin, in terms of its metabolism and elimination. Since curcumin is a highly hydrophobic molecule, similar to the proteins used in AnaBio’s micro-encapsulation system; this synergistic effect endorses curcumin uptake and bioavailability in the body.

Figure 5. Effect of thermal treatment at 100 °C in the load of Curcumin.

5. Enhanced Stability during long storage

Curcumin microcapsules generated by AnaBio Technologies LTD have been proven to remain stable in load and bioactivity (tested using the industry standard i.e. ABTS assay) for long term storage under refrigerated conditions. According to the Commission Regulation (EU) 10/2011, microcapsules were kept at 40 °C, 75 % RH for 10 days, to simulate a long storage.

Figure 6. Effect of storage time on the bioactivity of Curcumin microcapsules, compared to non-encapsulated curcumin extract. Results expressed as concentration of Curcumin (mg/L) that provides the same antioxidant activity than 0.1 M of standard Trolox solution.

6. Taste masking

Curcumin microcapsules generated by AnaBio Technologies LTD have been proven to remain stable in load and bioactivity (tested using the industry standard i.e. ABTS assay) for long term storage under refrigerated conditions. According to the Commission Regulation (EU) 10/2011, microcapsules were kept at 40 °C, 75 % RH for 10 days, to simulate a long storage.

References

Wang, S., Melnyk, J. P., Tsao, R., & Marcone, M. F. (2011). How natural dietary antioxidants in fruits, vegetables and legumes promote vascular health. Food Research International, 44(1), 14-22.

Valenzuela, A., Sanhueza, J., & Nieto, S. (2003). Natural antioxidants in functional foods: from food safety to health benefits. Grasas y aceites, 54(3), 295-303.

Pingitore, A., Lima, G. P. P., Mastorci, F., Quinones, A., Iervasi, G., & Vassalle, C. (2015). Exercise and oxidative stress: Potential effects of antioxidant dietary strategies in sports. Nutrition, 31(7-8), 916–922.

Delecroix, B., Abaïdia, A. E., Leduc, C., Dawson, B., & Dupont, G. (2017). Curcumin and piperine supplementation and recovery following exercise induced muscle damage: A randomized controlled trial. Journal of sports science & medicine, 16(1), 147.

AnaBio has generated “platform” technologies that with a proven track-record for broad spectrum market introduction of commercially viable, value-added encapsulation systems. This allows AnaBio clients to penetrate value-added niche markets in an economical cost-efficient manner.

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